Nene Humphrey has exhibited in numerous museums and galleries since coming to New York in 1979. Exhibitions include the McNay Art Museum, in San Antonio, TX; Mead Museum, in Amherst, MA; Palmer Museum, in PA; High Museum of Art, in Atlanta, GA; and the Sculpture Center, PS1 Contemporary Art Center, and the Lesley Heller Gallery, all in New York, NY.
Humphrey has received awards from the National Endowment for the Arts, The Rockefeller Foundation, Brown Foundation, and Anonymous was a Woman, among others. Her work has been written about in numerous publications including the New York Times, Art in America and ArtNews and Sculpture Magazine.
Since 2005 she has been artist in residence at the Joseph LeDoux neuroscience lab at NYU where her work has focused on explorations of the brain mechanisms underlying human emotions.